AMD 3465 (Standard)

CAT: 0804-HY-15971AR-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15971AR-01Size:1 mg
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Description
AMD 3465 (Standard) is the analytical standard of AMD 3465. This product is intended for research and analytical applications. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.
CAS Number
[185991-24-6]
UNSPSC
12352100
Target
CXCR; HIV; Reference Standards
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Others
Field of Research
Infection; Endocrinology
Smiles
C1(CNCC2=CC=C(CN3CCNCCCNCCNCCC3)C=C2)=NC=CC=C1
Molecular Formula
C24H38N6
Molecular Weight
410.60
References & Citations
[1]Hatse S, et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol. 2005 Sep 1;70 (5) :752-61.|[2]Yang L, et al. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res. 2007 Jan 15;67 (2) :651-8.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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