BRL-44408

CAT: 0804-HY-12716Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-12716Size:1 Each
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Description
BRL-44408 is a selective adrenergic receptor antagonist of α2A/α2B AR. BRL-44408 can effectively antagonize the inhibitory effects of norepinephrine or adrenergic receptor agonist Clonidine (HY-12721) on K+-induced [3H]norepinephrine and [3H]5-hydroxytryptamine release. BRL-44408 has a higher affinity for human platelet membranes containing α2A-adrenoceptors than BRL-41992 and Imiloxan (HY-101337) . BRL-44408 may affect the release of norepinephrine and 5-hydroxytryptamine through a mechanism mediated by α2A-adrenoceptors, and has a potential role in the regulation of neurotransmitter release[1].
CAS Number
[118343-19-4]
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/brl-44408.html
Smiles
CC1N(CC2=NCCN2)CC3=C1C=CC=C3
Molecular Formula
C13H17N3
Molecular Weight
215.29
References & Citations
[1]Further Studies on a2-Adrenofeptor Subtypes Involved in the Modulation of [ HINoradrenaline and [3H]5-Hydroxytryptamine Release from Rat Brain Cortex Synaptosomes
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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004562BRL 44408
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A13399-10BRL 44408 maleate 10mg
A13399-50BRL 44408 maleate 50mg
A13399-25BRL 44408 maleate 25mg
A13399-100BRL 44408 maleate 100mg

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