BRL 34778

• Description :

  BRL 34778 is a potent, selective and orally active dopamine D2 receptor antagonist with a Ki of 2.14 nM. BRL 34778 exhibits antipsychotic activity with low activity for extrapyramidal effects and sedation. BRL 34778 can be used for the research of neurological disease, such as schizophrenia[1].

• CAS Number :

  [86580-77-0]

• UNSPSC :

  12352005

• Target :

  Dopamine Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(C1=C(C=C(N)C(Cl)=C1)OC)N[C@@H](C[C@@H]2CCC3)C[C@@H]3N2CC4=CC=C(F)C=C4

• Molecular Formula :

  C23H27ClFN3O2

• Molecular Weight :

  431.93

• References & Citations :

  [1]Brown F, et al. The selective dopamine antagonist properties of BRL 34778: a novel substituted benzamide. Psychopharmacology (Berl) . 1988;94 (3) :350-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  D2 Receptor