BRL-32872

• Description:

  BRL-32872 is a potent human ether-a-go-go-related gene (hERG) potassium channel blocker (IC50=241 nM in isolated cardiomyocytes; 19.8 nM in HEK293 cells) . BRL-32872 is promising for research of cardiac arrhythmias (e.g., atrial/ventricular rhythms) [1].

• UNSPSC:

  12352005

• Target:

  Potassium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C(N(C1=CC=C(OC)C(OC)=C1)CCCN(CCC2=CC=C(OC)C(OC)=C2)C)C3=CC=C([N+]([O-])=O)C=C3.Cl

• Molecular Formula:

  C29H36ClN3O7

• Molecular Weight:

  574.07

• References & Citations:

  [1]Thomas D, et al. High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872. J Pharmacol Exp Ther. 2001 May;297 (2) :753-61.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [113241-47-7]