BRL-32872

CAT: 0804-HY-19117Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19117Size:1 Each
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Description
BRL-32872 is a potent human ether-a-go-go-related gene (hERG) potassium channel blocker (IC50=241 nM in isolated cardiomyocytes; 19.8 nM in HEK293 cells) . BRL-32872 is promising for research of cardiac arrhythmias (e.g., atrial/ventricular rhythms) [1].
CAS Number
[113241-47-7]
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Smiles
O=C(N(C1=CC=C(OC)C(OC)=C1)CCCN(CCC2=CC=C(OC)C(OC)=C2)C)C3=CC=C([N+]([O-])=O)C=C3.Cl
Molecular Formula
C29H36ClN3O7
Molecular Weight
574.07
References & Citations
[1]Thomas D, et al. High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872. J Pharmacol Exp Ther. 2001 May;297 (2) :753-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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