BRL-52656

• Description :

  BRL-52656 is a blood-brain barrier (BBB) -penetrable KOR receptor agonist that exhibits a biphasic effect. At low doses, BRL-52656 decreases blood pressure, whereas high doses have the opposite effect in spontaneously hypertensive rats. Additionally, BRL-52656 induces water diuresis by inhibiting the secretion of vasopressin (AVP) [1][2].

• CAS Number :

  [115642-84-7]

• UNSPSC :

  12352005

• Target :

  Opioid Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Cardiovascular Disease

• Smiles :

  FC(F)(F)C(C=C1)=CC=C1CC(N(CCCC2)[C@@H]2CN3CCCC3)=O.Cl

• Molecular Formula :

  C19H26ClF3N2O

• Molecular Weight :

  390.87

• References & Citations :

  [1]Brooks DP, et al. Opiate receptors within the blood-brain barrier mediate kappa agonist-induced water diuresis. J Pharmacol Exp Ther. 1993 Jul;266 (1) :164-71.|[2]Sako MO, et al. Filtering the Signal: Kappa Opioid Receptors in the Kidney. Function (Oxf) . 2025 Sep 15;6 (5) :zqaf042.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  κ Opioid Receptor/KOR