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CX-5461 (Standard)

CAT: 0804-HY-13323R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13323R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CX-5461 (Standard) is the analytical standard of CX-5461. This product is intended for research and analytical applications. CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively[1].
CAS Number
1138549-36-6
UNSPSC
12352005
Target
DNA/RNA Synthesis; Reference Standards
Type
Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cx-5461-standard.html
Smiles
CC1=NC=C(CNC(C2=C3N(C4=NC(N5CCN(CCC5)C)=CC=C4C2=O)C6=C(S3)C=CC=C6)=O)N=C1
Molecular Formula
C27H27N7O2S
Molecular Weight
513.61
References & Citations
[1]Drygin D et al. Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth. Cancer Res. 2011 Feb 15;71 (4) :1418-30.|[2]Bywater MJ, et al. Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53. Cancer Cell. 2012 Jul 10;22 (1) :51-65.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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