CX-659S

• Description :

  CX-659S is an orally active and novel derivative of 5-carboxamide uracil. CX-659S can effectively inhibit lipid peroxidation (IC50 = 5.9 μM) . CX-659S can reduce the infiltration of neutrophils and eosinophils. CX-659S inhibits the mRNA expression of pro-inflammatory cytokines IL-1β and TNF-α. CX-659S can be used for research on inflammatory conditions[1].

• UNSPSC :

  12352005

• Target :

  Interleukin Related; TNF Receptor

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  CC1=C2C(CC[C@](C)(O2)C(NC3=C(N(C4=CC=CC=C4)C(N(C3=O)C)=O)N)=O)=C(C(O)=C1C)C

• Molecular Formula :

  C25H28N4O5

• Molecular Weight :

  464.51

• References & Citations :

  [1]Tobe M, et al. Synthesis and biological evaluation of CX-659S and its related compounds for their inhibitory effects on the delayed-type hypersensitivity reaction. Bioorg Med Chem. 2000 Aug;8 (8) :2037-47. |[2]Goto Y, et al. Suppressive effect of topically applied CX-659S, a novel diaminouracil derivative, on the contact hypersensitivity reaction in various animal models. Int Arch Allergy Immunol. 2000 Dec;123 (4) :341-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IL-1

• CAS Number :

  [204980-81-4]