CX-5011

• UNSPSC Description:

  CX-5011 is a CK2 inhibitor. CX-5011 also induces Rac1 activation. CX-5011 induces apoptosis and induces cancer cell death[1][2].

• Target Antigen:

  Apoptosis; Casein Kinase; Ras

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;GPCR/G Protein;MAPK/ERK Pathway;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cx-5011.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=C2C3=CN=CN=C3C(NC4=CC=CC(C#C)=C4)=NC2=C1)O[Na]

• Molecular Weight:

  362.32

• References & Citations:

  [1]D'Amore C, et al. "Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms. Biochim Biophys Acta Mol Cell Res. 2020 Nov;1867(11):118807.|[2]Salizzato V, et al. Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. Oncotarget. 2016 Apr 5;7(14):18204-18.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1333382-30-1