CX-5011

CAT: 0804-HY-50733A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-50733A-01Size:5 mg
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Description
CX-5011 is a CK2 inhibitor. CX-5011 also induces Rac1 activation. CX-5011 induces apoptosis and induces cancer cell death[1][2].
CAS Number
[1333382-30-1]
UNSPSC
12352005
Target
Apoptosis; Casein Kinase; Ras
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cx-5011.html
Purity
99.48
Solubility
DMSO : 3.64 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C2C3=CN=CN=C3C(NC4=CC=CC(C#C)=C4)=NC2=C1)O[Na]
Molecular Formula
C20H11N4NaO2
Molecular Weight
362.32
References & Citations
[1]D'Amore C, et al. "Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms. Biochim Biophys Acta Mol Cell Res. 2020 Nov;1867 (11) :118807.|[2]Salizzato V, et al. Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. Oncotarget. 2016 Apr 5;7 (14) :18204-18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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