BM-1074

• Description:

  BM-1074 is a potent and specific Bcl-2/Bcl-xL inhibitor with Ki values of IC50 values of 1.8 nM and 6.9 nM for Bcl-2 and Bcl-xL, respectively. BM-1074 induces apoptosis, and exhibits antiproliferative activity against four small-cell lung cancer cell lines (H146, H1963, H187 and H1417) with IC50 values of 1-2 nM[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Apoptosis; Bcl-2 Family

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bm-1074.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C(C)N(C(C)C)C(C2=CC=C(Cl)C=C2)=C1C3=CC=CC(N4CCN(C5=CC=C(NS(=O)(C6=CC=C(N[C@H](CCN(C)C)CSC7=CC=CC=C7)C([N+]([O-])=O)=C6)=O)C=C5)CC4)=C3)NS(=O)(C)=O

• Molecular Formula:

  C50H57ClN8O7S3

• Molecular Weight:

  1013.69

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Angelo Aguilar, et al. A potent and highly efficacious Bcl-2/Bcl-xL inhibitor. J Med Chem. 2013 Apr 11;56 (7) :3048-3067.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Bcl-2; Bcl-xL

• CAS Number:

  1391108-10-3