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RI-962

CAT: 0013-GTR19248915-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19248915-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RI-962 is a potent and selective RIPK1 inhibitor that blocks necroptosis. It prevents phosphorylation of RIPK1, RIPK3, and MLKL with low nanomolar EC50 values in cellular models and demonstrates protective efficacy in murine inflammation studies, supporting its use in necroptosis-related disease research.
CAS Number
2763831-53-2
Product Name Alternative
RI962
Field of Research
Cell Biology, Signal Transduction
Purity
99.39% (May vary between batches)
Smiles
O=C (NC (C=1C=CC=CC1) C) C2=CN (C=3C=CC (=CC23) C=4C=CN5N=C (N=C5C4) NC (=O) C (C) C) C
Molecular Formula
C28H28N6O2
Molecular Weight
480.56
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 165437244
CAS Number2763831-53-2
PubChem CID165437244
IUPAC Name1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-(1-phenylethyl)indole-3-carboxamide
Molecular FormulaC28H28N6O2
Molecular Weight480.6
XLogP4.2
Topological Polar Surface Area93.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count36
Formal Charge0
Complexity786
SMILES
CC(C)C(=O)NC1=NN2C=CC(=CC2=N1)C3=CC4=C(C=C3)N(C=C4C(=O)NC(C)C5=CC=CC=C5)C
InChI
InChI=1S/C28H28N6O2/c1-17(2)26(35)31-28-30-25-15-21(12-13-34(25)32-28)20-10-11-24-22(14-20)23(16-33(24)4)27(36)29-18(3)19-8-6-5-7-9-19/h5-18H,1-4H3,(H,29,36)(H,31,32,35)
InChIKey
XYAYQAFPZOGMAA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 165437244
CAS: 2763831-53-2
CID: 165437244
Formula: C28H28N6O2
MW: 480.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight480.6
XLogP34.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass480.22737416
Monoisotopic Mass480.22737416
Topological Polar Surface Area93.3 Ų
Heavy Atom Count36
Formal Charge0
Complexity786
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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