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EAA2 rabbit pAb

CAT: 0855-ES20418-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20418-01Size:50 µL
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Background
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]
Description
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],
UniProt
P43004
Swiss Prot
P43004
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human EAA2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein .
Other Product Names
Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2)
Gene ID (Human)
6506

UniProtKB · P43004

Excitatory amino acid transporter 2

EAA2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P43004
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SLC1A2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DQE9, Q14417, Q541G6, U3KQQ4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Amino-acid transportSymportTransport

Cellular component

Cell membraneMembrane

Ligand

ChlorideMetal-bindingPotassiumSodium

Disease

Disease variantEpilepsy

PTM

GlycoproteinLipoproteinPalmitatePhosphoprotein

Domain

TransmembraneTransmembrane helix

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