EAA2 rabbit pAb

• Background:

  This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]

• Description:

  This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],

• Synonyms:

  Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II;Sodium-dependent glutamate/aspartate transporter 2;Solute carrier family 1 member 2)

• Gene ID:

  6506

• UniProt:

  P43004

• Cellular Locus:

  Cell membrane ; Multi-pass membrane protein.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human EAA2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000-2000 ELISA 1:5000-20000

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Subcellular Location:

  Cell membrane ; Multi-pass membrane protein .

• Other Product Names:

  Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2)

• Gene ID (Human):

  6506

• SwissProt (Human):

  P43004