st-Ht31

• UNSPSC Description:

  st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage[1][2].

• Target Antigen:

  PAK

• Type:

  Peptides

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/st-ht31.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)=O)C)=O)=O)C)=O)C)=O)CCCCN)=O)[C@@H](C)C)=O)CCC(N)=O)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCCCCCCCCCCCCC)=O)CC(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)C)=O)CO)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)C(C)C)=O)CC(O)=O)=O)C)=O)C(C)C)=O)[C@H](CC)C)=O)CCC(O)=O

• Molecular Weight:

  2798.32

• References & Citations:

  [1]Ma L, et al. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 2011 Feb 4;286(5):3370-8. |[2]Rahamim Ben-Navi L, et al. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Sci Rep. 2016 Nov 30;6:37922.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  188425-80-1