CTOP (TFA)

• Description:

  CTOP TFA is a potent and highly selective μ-opioid receptor antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomotor activity[1][2].

• UNSPSC:

  12352209

• Target:

  Opioid Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ctop-tfa.html

• Purity:

  99.84

• Solubility:

  H2O : 50 mg/mL (ultrasonic)

• Smiles:

  OC (C (F) (F) F) =O.O=C (N[C@@H]1CC2=CNC3=CC=CC=C23) [C@H] (CC4=CC=C (O) C=C4) NC ([C@@H] (NC ([C@@H] (CC5=CC=CC=C5) N) =O) CSSC ([C@@H] (C (N[C@@H] ([C@@H] (C) O) C (N) =O) =O) NC ([C@] ([H]) ([C@@H] (C) O) NC ([C@H] (CCCN) NC1=O) =O) =O) (C) C) =O.[x]

• Molecular Formula:

  C50H67N11O11S2.xC2HF3O2

• Molecular Weight:

  1062.27 (free base)

• References & Citations:

  [1]Gulya K, et al. Central effects of the potent and highly selective μ opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice. Eur J Pharmacol. 1988 Jun 10;150 (3) :355-60.|[2]Badiani A, et al. Intra-VTA injections of the mu-opioid antagonist CTOP enhance locomotor activity. Brain Res. 1995 Aug 28;690 (1) :112-6.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  μ Opioid Receptor/MOR