CTOP

• Description:

  CTOP is a potent and highly selective μ-opioid receptor antagonist. CTOP antagonizes the acute morphine-induced analgesic effect and hypermotility. CTOP enhances extracellular dopamine levels in the nucleus accumbens. CTOP dose-dependently enhances locomotor activity[1][2].

• UNSPSC:

  12352209

• Target:

  Opioid Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ctop.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C (C=1C=2C (NC1) =CC=CC2) [C@H]3NC (=O) [C@H] (CC4=CC=C (O) C=C4) NC (=O) [C@@H] (NC ([C@@H] (CC5=CC=CC=C5) N) =O) CSSC (C) (C) [C@@H] (C (N[C@@H] ([C@@H] (C) O) C (N) =O) =O) NC (=O) [C@] ([C@@H] (C) O) (NC (=O) [C@H] (CCCN) NC3=O) [H]

• Molecular Formula:

  C50H67N11O11S2

• Molecular Weight:

  1062.26

• References & Citations:

  [1]Gulya K, et al. Central effects of the potent and highly selective μ opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice. Eur J Pharmacol. 1988 Jun 10;150 (3) :355-60.|[2]Badiani A, et al. Intra-VTA injections of the mu-opioid antagonist CTOP enhance locomotor activity. Brain Res. 1995 Aug 28;690 (1) :112-6.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  μ Opioid Receptor/MOR

• CAS Number:

  103429-31-8