PF-06649298

CAT: 0804-HY-120103-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-120103-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

PF-06649298 is a sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor. PF-06649298 specifically interacts with NaCT with an IC50 value of 16.2 μM to inhibits the transport of citrate in human hepatocytes. PF-06649298 can be used for the research of regulating glucose metabolism and lipid metabolism[1][2].

CAS Number

1854061-16-7

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pf-06649298.html

Concentration

10mM

Purity

98.32

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@](O)(CCC1=CC=C(C(C)(C)C)C=C1)CC(O)=O

Molecular Formula

C16H22O5

Molecular Weight

294.34

References & Citations

[1]Huard K, et al. Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem. 2016 Feb 11;59 (3) :1165-75.|[2]Huard K, et al. Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5) . Sci Rep. 2015 Dec 1;5:17391.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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HY-124317	PF-06649283
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HY-10459-01	PF-562271
HY-108341-01	PF-06424439
HY-100398-01	PF-04979064
HY-131972-01	PF-06843195
HY-14464-01	PF-00489791
HY-121163-01	PF-184563
HY-124947	PF-4522654

Alternative Products

Catalog	Name
BA6981-10	PF-06649298
MBS579460	PF-03084014 (PF-3084014)
M36412-01	PF-17
M34376-01	PF-184298
M33060-01	PF-04957325
M28021-01	PF-1355
M26783-01	PF-04937319
M26368-01	PF-04885614
M24156-01	PF-9363
M23628-01	PF-06424439

PF-06649298

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