EcDsbB-IN-9

• Description:

  EcDsbB-IN-9 (Compound 9) is a potent E. coli DsbB (EcDsbB) inhibitor with an IC50 of 1.7 μM and a Ki of 46 nM[1].

• Product Name Alternative:

  9-Amino-20(S)-camptothecin; 9-Amino-CPT

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/ecdsbb-in-9.html

• Concentration:

  10mM

• Purity:

  97.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1C(Cl)=C(C=NN1CC2=CC=CC=C2)Cl

• Molecular Formula:

  C11H8Cl2N2O

• Molecular Weight:

  255.10

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Landeta C, et al. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nat Chem Biol. 2015 Apr;11 (4) :292-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [41933-33-9]