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Azido-PEG2-C2-Boc

CAT: 0804-HY-140776-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140776-01Size:100 mg
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Description
Azido-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
1271728-79-0
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg2-c2-boc.html
Purity
96.0
Solubility
10 mM in DMSO
Smiles
O=C(OC(C)(C)C)CCOCCOCCN=[N+]=[N-]
Molecular Formula
C11H21N3O4
Molecular Weight
259.30
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

Chemical Information

Azido-peg2-T-butyl ester
CAS Number1271728-79-0
PubChem CID60146180
IUPAC Nametert-butyl 3-[2-(2-azidoethoxy)ethoxy]propanoate
Molecular FormulaC11H21N3O4
Molecular Weight259.30
XLogP1.6
Topological Polar Surface Area59.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Heavy Atom Count18
Formal Charge0
Complexity283
SMILES
CC(C)(C)OC(=O)CCOCCOCCN=[N+]=[N-]
InChI
InChI=1S/C11H21N3O4/c1-11(2,3)18-10(15)4-6-16-8-9-17-7-5-13-14-12/h4-9H2,1-3H3
InChIKey
LSMDUZQBNBZFEA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azido-peg2-T-butyl ester
CAS: 1271728-79-0
CID: 60146180
Formula: C11H21N3O4
MW: 259.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight259.30
XLogP31.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Exact Mass259.15320616
Monoisotopic Mass259.15320616
Topological Polar Surface Area59.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity283
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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