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Azido-C2-SS-PEG2-C2-acid

CAT: 0804-HY-140101Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-140101Size:1 Each
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Description
Azido-C2-SS-PEG2-C2-acid is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Azido-C2-SS-PEG2-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
2144777-72-8
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-c2-ss-peg2-c2-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CCOCCOCCSSCCN=[N+]=[N-]
Molecular Formula
C9H17N3O4S2
Molecular Weight
295.38
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker

Chemical Information

Azido-SS-PEG2-acid
CAS Number2144777-72-8
PubChem CID131709264
IUPAC Name3-[2-[2-(2-azidoethyldisulfanyl)ethoxy]ethoxy]propanoic acid
Molecular FormulaC9H17N3O4S2
Molecular Weight295.4
XLogP1
Topological Polar Surface Area121
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count13
Heavy Atom Count18
Formal Charge0
Complexity262
SMILES
C(COCCOCCSSCCN=[N+]=[N-])C(=O)O
InChI
InChI=1S/C9H17N3O4S2/c10-12-11-2-7-17-18-8-6-16-5-4-15-3-1-9(13)14/h1-8H2,(H,13,14)
InChIKey
UGKCXCCDJZIEBX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azido-SS-PEG2-acid
CAS: 2144777-72-8
CID: 131709264
Formula: C9H17N3O4S2
MW: 295.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight295.4
XLogP31
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count13
Exact Mass295.06604838
Monoisotopic Mass295.06604838
Topological Polar Surface Area121 Ų
Heavy Atom Count18
Formal Charge0
Complexity262
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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