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Azido-PEG2-C2-amine

CAT: 0804-HY-140213-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140213-01Size:100 mg
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Description
Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2]. Azido-PEG2-C2-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
166388-57-4
Product Name Alternative
N3-PEG2-CH2CH2NH2
UNSPSC
12352203
Hazard Statement
H314
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg2-c2-amine.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
[N-]=[N+]=NCCOCCOCCN
Molecular Formula
C6H14N4O2
Molecular Weight
174.20
Precautions
H314
References & Citations
[1]Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62 (16) :7575-7582.|[2]Tominari, Yusuk , et al. Heterocyclic compound. WO2020027225A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers

Chemical Information

Azido-PEG2-Amine
CAS Number166388-57-4
PubChem CID53401015
IUPAC Name2-[2-(2-azidoethoxy)ethoxy]ethanamine
Molecular FormulaC6H14N4O2
Molecular Weight174.20
XLogP-0.1
Topological Polar Surface Area58.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count12
Formal Charge0
Complexity136
SMILES
C(COCCOCCN=[N+]=[N-])N
InChI
InChI=1S/C6H14N4O2/c7-1-3-11-5-6-12-4-2-9-10-8/h1-7H2
InChIKey
ZHWGWSYNZIZTFL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azido-PEG2-Amine
CAS: 166388-57-4
CID: 53401015
Formula: C6H14N4O2
MW: 174.20
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight174.20
XLogP3-0.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass174.11167570
Monoisotopic Mass174.11167570
Topological Polar Surface Area58.8 Ų
Heavy Atom Count12
Formal Charge0
Complexity136
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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