NH2-PEG2-C2-Boc

NH2-PEG2-C2-Boc

• CAS Number: 756525-95-8
• UNSPSC Description: NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
• Target Antigen: ADC Linker; PROTAC Linkers
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/nh2-peg2-c2-boc.html
• Purity: 99.62
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: NCCOCCOCCC(OC(C)(C)C)=O
• Molecular Weight: 233.30
• References & Citations: [1]Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 24;62(2):941-964.|[2]Joshua D. Thomas, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported