(±) 11 (12) -EET methyl ester-d11

• Description :

  (±) 11 (12) -EET-d11 methyl ester (11,12-EET methyl ester-d11) is the deuterium labeled (±) 11 (12) -EET methyl ester (HY-139938) . (±) 11 (12) -EET methyl ester (11,12-EET-methyl ester) is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494) . (±) 11 (12) -EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±) 11 (12) -EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±) 11 (12) -EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis[1][2].

• Product Name Alternative :

  11,12-EET methyl ester-d11; (±) 11,12-EpETrE methyl ester-d11

• UNSPSC :

  12352005

• Target :

  Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Others

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease

• Solubility :

  10 mM in DMSO

• Smiles :

  [2H]C([2H])(C([2H])(/C=C\C[C@@H]1[C@H](C/C=C\C/C=C\CCCC(OC)=O)O1)[2H])C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H]

• Molecular Formula :

  C21H23D11O3

• Molecular Weight :

  345.56

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Lahvic JL, et al. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported