GSK864

CAT: 0804-HY-19540-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19540-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
GSK864, a chemical probe, is an isocitrate dehydrogenase 1 (IDH1) mutant inhibitor; inhibits IDH1 mutants R132C, R132H, and R132G with IC50 values of 8.8, 15.2 and 16.6 nM.
CAS Number
[1816331-66-4]
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GSK864.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C=C1)=CC=C1CN2N=C(C(NC3=CC(C)=C(OC)C(C)=C3)=O)C4=C2[C@](C(N)=O)(C)CN(C(C5=CC=CN5)=O)C4
Molecular Formula
C30H31FN6O4
Molecular Weight
558.60
References & Citations
[1]Okoye-Okafor UC, et al. New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nat Chem Biol. 2015 Nov;11 (11) :878-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH1

Related Products

CatalogName
HY-157294-01GSK866
HY-119608-01GSK854
HY-157294A-01(R) -GSK866
HY-157294B(Rac) -GSK866
HY-123606-01GSK484
HY-111941-01GSK8612
HY-148591-01GSK761
HY-116761-01GSK467
HY-115867-01GSK852
HY-104021-01GSK840

Alternative Products

CatalogName
MBS3845178-01GSK864
A20737-100GSK864 100mg
A20737-25GSK864 25mg
A20737-50GSK864 50mg
A20737-1GSK864 1mg
A20737-5GSK864 5mg
A20737-10GSK864 10mg
A20737-10mM-DGSK864 10mM * 1mL in DMSO

Popular Products