GSK343

• Description:

  GSK343, a chemical probe, is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Autophagy; Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/GSK343.html

• Purity:

  99.46

• Solubility:

  DMSO : 15.62 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(C1=CC(C2=CC(N3CCN(C)CC3)=NC=C2)=CC4=C1C=NN4C(C)C)NCC5=C(CCC)C=C(C)NC5=O

• Molecular Formula:

  C31H39N7O2

• Molecular Weight:

  541.69

• Precautions:

  H302

• References & Citations:

  [1]Sharad K, et al. Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3 (12) :1091-6.|[2]Ding M, et al. The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer. Clin Exp Pharmacol Physiol. 2015 May;42 (5) :458-64.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  EZH2

• CAS Number:

  [1346704-33-3]