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Biotin-ProTx-I

CAT: 0466-PTB001-00100Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0466-PTB001-00100Size:0.1 mg
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Description
Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula) . This toxin reversibly inhibits the tetrodotoxin (TTX) -resistant channel Nav1.8 (IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. Biotin-ProTx-I is a biotin-tagged version of ProTx-I.
Specifications
Blocker of voltage-gated sodium channels and T-type Cav channels
Target
Ca channels
Sequence
ECRYWLGGCSAGQTCCKHLVCSRRHGWCVWDGTFS
Peptide Number
PTB001
Disulfide Bonds
Cys2-Cys16; Cys9-Cys21; Cys15-Cys25
N Terminal Sequence
Biotin
C Terminal Sequence
OH

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