Cy5-ProTx-I

CAT: 0466-PTF001-50010Size: 5x 0.01 mgDry Ice: NoHazardous: No
CAT#:0466-PTF001-50010Size:5x 0.01 mg
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Description
Cy5-ProTx-I (Protoxin 1; β-theraphotoxin-Tp1a) is a fluorescently labeled ProTx-I that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula) . This toxin reversibly inhibits the tetrodotoxin (TTX) -resistant channel Nav1.8 (IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2. ProTx-I is also an antagonist of TRAP1.
Specifications
Blocker of voltage-gated sodium channels and T-type Cav
Target
Na channels
Sequence
YCQKWMWTCDSERKCCEGMVCRLWCKKKLW
Peptide Number
PTF001
Disulfide Bonds
Cys2-Cys16; Cys9-Cys21; Cys15-Cys28
N Terminal Sequence
Cy5
C Terminal Sequence
OH

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