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BAY-8400

CAT: 0804-HY-132293-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132293-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM) . BAY-8400 can be used for the research of cancer[1].
CAS Number
2763602-59-9
UNSPSC
12352005
Target
DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay-8400.html
Concentration
10mM
Purity
99.38
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(C1=CC(C2=CC=C3N=CC4=NN=C(N4C3=C2)C5=CCCOCC5)=CN=C1)F
Molecular Formula
C21H17F2N5O
Molecular Weight
393.39
References & Citations
[1]Berger M, et al. BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies [published online ahead of print, 2021 Aug 24]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00762.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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