mAChR antagonist 1

• UNSPSC Description:

  mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively[1].

• Target Antigen:

  mAChR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/machr-antagonist-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CN1CCC(CC1)OC(N(C2=CC=CC=C2)C3=CC=CC=C3)=O

• Molecular Weight:

  310.39

• References & Citations:

  [1]Marlon Millard, et al. Design, synthesis and preclinical evaluation of muscarine receptor antagonists via a scaffold-hopping approach. Eur J Med Chem. 2023 Oct 21:262:115891.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  101491-79-6