M4 mAChR Modulator-1

• UNSPSC Description:

  M4 mAChR Modulator-1 (compound 23i) is a M4 mAChR positive allosteric modulator (PAM). M4 mAChR Modulator-1 exhibits significantly greater cooperativity with ACh in β-arrestin recruitment over G protein activation. M4 mAChR Modulator-1 displays weak PAM effect in G protein-mediated responses, but strong PAM effect in β-arrestin recruitment[1].

• Target Antigen:

  mAChR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/m4-machr-modulator-1.html

• Smiles:

  O=C1NCC2=C1C=C(C3=NC(C)=NC=C3C4=CN(CC5CCCC5)N=C4)C=C2

• Molecular Weight:

  373.45

• References & Citations:

  [1]Liu B, et al. Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders. J Med Chem. 2024 Jul 18.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported