M4 mAChR agonist-1

• UNSPSC Description:

  M4 mAChR agonist-1 (compound 10a) is a potent M4 mAChR agonist with an EC50 >10 μM for human M4[1].

• Target Antigen:

  mAChR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/m4-machr-agonist-1.html

• Solubility:

  DMSO : 20 mg/mL (ultrasonic;warming;adjust pH to 3 with HCl;heat to 70°C)

• Smiles:

  O=C(C1CCN(CC1)C2=C3C(C)=C(C)SC3=NC=N2)N

• Molecular Weight:

  290.38

• References & Citations:

  [1]Wood MR, et al. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2016;26(13):3029-3033.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  785705-53-5