Ginsenoside Rk1

CAT: 0804-HY-N2515-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-N2515-01Size:5 mg

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Description

Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures[1]. Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB[2]. Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis[1]. Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway[3].

CAS Number

494753-69-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; JAK; NF-κB; PI3K

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; JAK/STAT Signaling; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ginsenoside-rk1.html

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

Smiles

C[C@]12[C@@](C[C@@H](O)[C@@]3([H])[C@]2(CC[C@@H]3C(CC/C=C(C)/C)=C)C)([H])[C@@]4([C@@](C(C)([C@@H](O[C@@]5([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O5)O)O[C@]6([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)CO)CC4)C)([H])CC1)C

Molecular Formula

C42H70O12

Molecular Weight

767.00

Precautions

H302, H315, H319, H335

References & Citations

[1]Elshafay A, et al. Ginsenoside Rk1 bioactivity: a systematic review. PeerJ. 2017 Nov 17;5:e3993.|[2]Yu Q, et al. Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway. Chin J Nat Med. 2017 Oct;15 (10) :751-757.|[3]Hong Y, et al. Ginsenoside Rk1 induces cell cycle arrest and apoptosis in MDA-MB-231 triple negative breast cancer cells. Toxicology. 2019 Apr 15;418:22-31.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Chemical Information

Ginsenoside Rk1

ginsenoside Rk1 has been reported in Panax notoginseng, Panax ginseng, and Centella asiatica with data available.

CAS Number	494753-69-4
PubChem CID	11499198
IUPAC Name	(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-(6-methylhepta-1,5-dien-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
Molecular Formula	C42H70O12
Molecular Weight	767.0
XLogP	5.4
Topological Polar Surface Area	199
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	10
Heavy Atom Count	54
Formal Charge	0
Complexity	1370

SMILES

CC(=CCCC(=C)[C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)C

InChI

InChI=1S/C42H70O12/c1-21(2)10-9-11-22(3)23-12-16-42(8)30(23)24(45)18-28-40(6)15-14-29(39(4,5)27(40)13-17-41(28,42)7)53-38-36(34(49)32(47)26(20-44)52-38)54-37-35(50)33(48)31(46)25(19-43)51-37/h10,23-38,43-50H,3,9,11-20H2,1-2,4-8H3/t23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33+,34+,35-,36-,37+,38+,40+,41-,42-/m1/s1

InChIKey

KWDWBAISZWOAHD-MHOSXIPRSA-N

Chemical Structure

2D Structure

CAS: 494753-69-4

CID: 11499198

Formula: C42H70O12

MW: 767.0

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	767.0
XLogP3	5.4
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	10
Exact Mass	766.48672766
Monoisotopic Mass	766.48672766
Topological Polar Surface Area	199 Å²
Heavy Atom Count	54
Formal Charge	0
Complexity	1370
Isotope Atom Count	0
Defined Atom Stereocenter Count	19
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-N11226	Ginsenoside Ra0
HY-N0039-01	Ginsenoside Rb1
HY-N2516	Ginsenoside Rd2
HY-N2503-01	Ginsenoside F4
HY-N0906-01	Ginsenoside Rk3
HY-N0598-01	Ginsenoside F1
HY-N0043-01	Ginsenoside Rd
HY-N12366	Ginsenoside Rs1
HY-N6580-01	Ginsenoside Rg4
HY-108277-01	Ginsenoside F5

Alternative Products

Catalog	Name
OG31930-01	Ginsenoside Rk1 - Ginsenoside Rk1:Ginsenoside Rz1 (5:2)
300355	Ginsenoside Rg3 (20 (s) -Ginsenoside Rg3)
300354	Ginsenoside Rg2 (20 (s) -Ginsenoside Rg2)
N1613-5.1	Ginsenoside Rg1
N1619-20	Ginsenoside Rb2
CS-BS-00118	Ginsenoside F1
IDA45941-01	Ginsenoside Ra1
ZKA25028-01	Ginsenoside rc
OG31929-01	Ginsenoside Rk2
OG31928-01	Ginsenoside Rh4

Ginsenoside Rk1

Chemical Information

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