AMPK activator 2 (hydrochloride)

• UNSPSC Description:

  AMPK activator 2 (compound 7a) hydrochloride, a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549)[1].

• Target Antigen:

  AMPK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ampk-activator-2-hydrochloride.html

• Purity:

  99.65

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  N=C(NC(NC1=CC=C(C(F)(F)F)C=C1)=N)NCC(C)C.[H]Cl

• Molecular Weight:

  337.77

• References & Citations:

  [1]Di Xiao, et al. Synthesis, biological evaluation and anti-proliferative mechanism of fluorine-containing proguanil derivatives. Bioorg Med Chem. 2020 Jan 15;28(2):115258.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported