Naspm (trihydrochloride)

• Product Name Alternative:

  1-Naphthylacetyl spermine trihydrochloride

• CAS Number:

  1049731-36-3

• UNSPSC Description:

  Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

• Target Antigen:

  iGluR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Naspm-trihydrochloride.html

• Purity:

  98.50

• Solubility:

  DMSO : 6.4 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)

• Smiles:

  [H]Cl.[H]Cl.[H]Cl.O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1

• Molecular Weight:

  479.91

• References & Citations:

  [1]Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.Cell Rep. 2020 Nov 10;33(6):108369. |Cell Rep. 2023 Dec 3;42(12):113551.|iScience. 2023 Mar.|J Headache Pain. 2022 Aug 10;23(1):98.|Neurobiol Dis. 2024 Mar 8:106471.|Neuroscience. 2021 Sep 9;S0306-4522(21)00454-1.|Toxicol In Vitro. 2017 Oct;44:57-65.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported