Laduviglusib (trihydrochloride)

Laduviglusib (trihydrochloride)

• CAS Number: 1782235-14-6
• UNSPSC Description: Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy[1][2][3].
• Target Antigen: Autophagy; GSK-3; Organoid; Wnt; β-catenin
• Type: Reference compound
• Related Pathways: Autophagy;PI3K/Akt/mTOR;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/laduviglusib-trihydrochloride.html
• Purity: 99.35
• Solubility: DMSO : ≥ 32 mg/mL|H2O : 19 mg/mL (ultrasonic;warming)
• Smiles: N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl.[H]Cl.[H]Cl
• Molecular Weight: 574.72
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• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported