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HM03 (trihydrochloride)

CAT: 0804-HY-125974ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125974ASize:1 Each
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Description
HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity[1].
CAS Number
1082532-95-3
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hm03-trihydrochloride.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(NC2=C(C=C(OC)C=C3)C3=NC4=CC(Cl)=CC=C42)C=C1CN5CCN(C)CC5.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C26H30Cl4N4O2
Molecular Weight
572.35
References & Citations
[1]Huang M, et al. Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors. Bioorg Med Chem Lett. 2013;23 (10) :3044-3050.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSPA5

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