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Naspm (trihydrochloride)

CAT: 0804-HY-12506A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12506A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
CAS Number
1049731-36-3
Product Name Alternative
1-Naphthylacetyl spermine trihydrochloride
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Naspm-trihydrochloride.html
Purity
98.50
Solubility
DMSO : 6.4 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
[H]Cl.[H]Cl.[H]Cl.O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1
Molecular Formula
C22H37Cl3N4O
Molecular Weight
479.91
References & Citations
[1]Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29 (1) :27-36.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor
Citation 01
Cell Rep. 2020 Nov 10;33 (6) :108369.|Cell Rep. 2023 Dec 3;42 (12) :113551.|iScience. 2023 Mar 3;26 (4) :106322.|J Headache Pain. 2022 Aug 10;23 (1) :98.|Neurobiol Dis. 2024 May:194:106471.|Neuroscience. 2021 Nov 1:475:220-228.|Toxicol In Vitro. 2017 Oct:44:57-65.

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