RS-1

• Description :

  RS-1 is a RAD51 activator. RS-1 enhances the homologous recombination activity of human RAD51 by promoting the formation of active presynaptic filaments[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H319

• Target :

  CRISPR/Cas9; RAD51

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/RS-1.html

• Concentration :

  10mM

• Purity :

  99.77

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(NC1=CC=C(Br)C=C1)C2=CC=C(Br)C(S(=O)(NCC3=CC=CC=C3)=O)=C2

• Molecular Formula :

  C20H16Br2N2O3S

• Molecular Weight :

  524.23

• Precautions :

  H319

• References & Citations :

  [1]Jayathilaka K, et al. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Natl Acad Sci U S A. 2008 Oct 14;105 (41) :15848-53.|[2]Song J, et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016 Jan 28;7:10548.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [312756-74-4]