Enpp-1-IN-24

CAT: 0804-HY-168147Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-168147Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Enpp-1-IN-24 (compund 7) is an ENPP1 inhibitor that, in combination with anti-PD-1 antibodies, achieves 77.7% tumor growth inhibition and improves survival in mouse models[1].

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/enpp-1-in-24.html

Smiles

O=C(C1=CN2C(C(C3=C(OC)C=CC=C3F)=N1)=NC=C2)NC4=CC(F)=CC=C4N5CCC(NS(=O)(N)=O)CC5

Molecular Formula

C25H25F2N7O4S

Molecular Weight

557.57

References & Citations

[1]Zhan S, et al. Discovery of Imidazo[1,2-a]pyrazine Derivatives as Potent ENPP1 Inhibitors. J Med Chem. 2024 Oct 24;67 (20) :18317-18333.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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T200827-01	Enpp-1-IN-24
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BA8220-1	Enpp-1-IN-5
BA8154-25	Enpp-1-IN-14
T75126-01	Enpp-1-IN-15
T62903-01	Enpp-1-IN-6

Enpp-1-IN-24

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