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Desloratadine (Standard)

CAT: 0804-HY-B0539R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0539R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desloratadine (Standard) is the analytical standard of Desloratadine. This product is intended for research and analytical applications. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].
CAS Number
100643-71-8
Product Name Alternative
Sch34117 (Standard)
UNSPSC
12352005
Hazard Statement
H302-H318-H361-H411
Target
Drug Metabolite; Endogenous Metabolite; Histamine Receptor; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Inflammation/Immunology; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/desloratadine-standard.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1
Molecular Formula
C19H19ClN2
Molecular Weight
310.82
Precautions
P264-P270-P273-P280-P305+P351+P338-P330-P391-P405-P501
References & Citations
[1]McClellan K, et al. Desloratadine. Drugs. 2001;61 (6) :789-797.|[2]Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107 (4) : p. 751-62.|[3]Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31 (9) : p. 1369-77.|[4]Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H (1) receptor. Eur J Pharmacol, 2002. 449 (3) : p. 229-37.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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