Desloratadine-d4

• CAS Number:

  381727-29-3

• UNSPSC Description:

  Desloratadine-d4 is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

• Target Antigen:

  Endogenous Metabolite; Histamine Receptor; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling;Others

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Solubility:

  10 mM in DMSO

• Smiles:

  [2H]C(NC([2H])([2H])C/1)([2H])CC1=C2C3=CC=C(Cl)C=C3CCC4=CC=CN=C4\2

• Molecular Weight:

  314.85

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107(4): p. 751-62.|[3]Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31(9): p. 1369-77.|[4]Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor. Eur J Pharmacol, 2002. 449(3): p. 229-37.|[5]McClellan K, et al. Desloratadine. Drugs. 2001;61(6):789-797.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported