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Desloratadine-d4 (hydrobromide)

CAT: 0804-HY-B0539S4Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0539S4Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desloratadine-d4 hydrobromide is deuterated labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].
Product Name Alternative
Sch34117-d4 (hydrobromide)
UNSPSC
12352005
Target
Drug Metabolite; Endogenous Metabolite; Histamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
[2H]C(NC([2H])C/1[2H])C([2H])C1=C2C3=CC=C(Cl)C=C3CCC4=CC=CN=C4\2.Br
Molecular Formula
C19H16D4BrClN2
Molecular Weight
395.76
References & Citations
[1]McClellan K, et al. Desloratadine. Drugs. 2001;61 (6) :789-797.|[2]Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107 (4) : p. 751-62.|[3]Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31 (9) : p. 1369-77.|[4]Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H (1) receptor. Eur J Pharmacol, 2002. 449 (3) : p. 229-37.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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