Products for Research Use Only
RegisterLogin

Desloratadine-d5

CAT: 0804-HY-B0539S3-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0539S3-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Desloratadine-d5 is deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].
CAS Number
1020719-34-9
Product Name Alternative
Sch34117-d5
UNSPSC
12352005
Target
Endogenous Metabolite; Histamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Endocrinology
Purity
99.74
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(/C(C2=NC([2H])=C([2H])C([2H])=C2C([2H])([2H])C3)=C4CCNCC/4)C3=C1
Molecular Formula
C19H14D5ClN2
Molecular Weight
315.85
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H (1) receptor. Eur J Pharmacol, 2002. 449 (3) : p. 229-37.|[3]Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107 (4) : p. 751-62.|[4]McClellan K, et al. Desloratadine. Drugs. 2001;61 (6) :789-797.|[5]Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31 (9) : p. 1369-77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
H1 Receptor

Related Products

CatalogName
HY-B0539-01Desloratadine
HY-B0539S1-01Desloratadine-d9
HY-B0539R-01Desloratadine (Standard)
HY-B0539S-01Desloratadine-d4
HY-W741093-01N-Nitroso desloratadine
HY-134149-01N-Formyl desloratadine
HY-B0539S4Desloratadine-d4 (hydrobromide)
HY-1242453-Hydroxy desloratadine
HY-124245R3-Hydroxy desloratadine (Standard)
HY-W744212-01N-Nitroso desloratadine-d4

Alternative Products

CatalogName
TMIJ-0202-01Desloratadine-d5
sc-500440Desloratadine-d5 Hydrochloride
sc-484593N-Methyl Desloratadine-d5
AR-L07714-01N-Nitroso Desloratadine-d5
B1571-50Desloratadine

Popular Products