Desloratadine-d5

Desloratadine-d5

• CAS Number: 1020719-34-9
• UNSPSC Description: Desloratadine-d5 is deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].
• Target Antigen: Endogenous Metabolite; Histamine Receptor; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling;Others
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Inflammation/Immunology; Endocrinology
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC=C(/C(C2=NC([2H])=C([2H])C([2H])=C2C([2H])([2H])C3)=C4CCNCC/4)C3=C1
• Molecular Weight: 315.85
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor. Eur J Pharmacol, 2002. 449(3): p. 229-37.|[3]Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107(4): p. 751-62.|[4]McClellan K, et al. Desloratadine. Drugs. 2001;61(6):789-797.|[5]Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31(9): p. 1369-77.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported