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PF 03716556

CAT: 0804-HY-13100-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13100-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF 03716556 is a potent, selective, competitive and reversible acid pump (H+, K+-ATPase) antagonist with pIC50s of 6.026, 6.038 and 6.009 for porcine, canine, and human recombinant gastric H+, K+-ATPase, respectively. PF 03716556 is inactive against other receptors, ion channels, and enzymes. PF 03716556 has the potential for gastroesophageal reflux disease research[1].
CAS Number
928774-43-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Proton Pump
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/PF-03716556.html
Purity
99.10
Solubility
DMSO : 23 mg/mL (ultrasonic; warming)
Smiles
CC1=CN2C=C(C=C(C2=N1)N[C@H]3C4=C(C=CC=C4OCC3)C)C(N(CCO)C)=O
Molecular Formula
C22H26N4O3
Molecular Weight
394.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Hiroki Mori, et al. N- (2-hydroxyethyl) -N,2-dimethyl-8-{[ (4R) -5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. J Pharmacol Exp Ther. 2009 Feb;328 (2) :671-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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