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Hydroxy-PP-Me

CAT: 0804-HY-156694-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156694-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hydroxy-PP-Me is a selective CBR1 inhibitor with an IC50 of 759 nM. Hydroxy-PP-Me can inhibit serum starvation-induced apoptosis. Hydroxy-PP-Me can enhance the cytotoxic effects of Daunorubicin and As2O3 on tumor cells. Hydroxy-PP-Me can be used in the research of cancer such as leukemia[1][2].
CAS Number
833481-77-9
UNSPSC
12352005
Target
Apoptosis; NADPH Oxidase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hydroxy-pp-me.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=CC(C2=CN(C(C)C)C3=C2C(NC)=NC=N3)=C1
Molecular Formula
C16H18N4O
Molecular Weight
282.34
References & Citations
[1]Tanaka M, et al. An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol. 2005 May;3 (5) :e128.|[2]Jang M, et al. Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res. 2012 Aug 15;72 (16) :4214-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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