ME 3407

• Description :

  ME-3407 (EF-4040) is a H+-K+-ATPase redistribution disruptor and myosin light chain kinase (MLCK) and protein kinase A inhibitor. ME-3407 blocks gastric acid secretion and aminopyrine accumulation by inhibiting microsomal-to-apical membrane redistribution of H+-K+-ATPase and suppressing MLCK-mediated myosin light chain phosphorylation. ME-3407 is promising for research of peptic ulcer[1].

• Product Name Alternative :

  EF-4040

• UNSPSC :

  12352005

• Target :

  Myosin; Na+/K+ ATPase; PKA

• Related Pathways :

  Cytoskeleton; Membrane Transporter/Ion Channel; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Smiles :

  O=C(OCCCC)CS(C1=NC2=CC=CN=C2S1)=O

• Molecular Formula :

  C12H14N2O3S2

• Molecular Weight :

  298.38

• References & Citations :

  [1]Urushidani T, et al. ME-3407, a new antiulcer agent, inhibits acid secretion by interfering with redistribution of H (+) -K (+) -ATPase. Am J Physiol. 1997 May;272 (5 Pt 1) :G1122-34.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MLCK

• CAS Number :

  [133903-90-9]