CMPF

CAT: 0804-HY-129297-01Size: 500 µgDry Ice: NoHazardous: No

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CAT#:0804-HY-129297-01Size:500 µg

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Description

CMPF can be found in trace constituent of urine and blood. CMPF is a biomarker of type 2 diabetes. CMPF can act on the β cell and induces impaired mitochondrial function. CMPF decreases glucose-induced ATP accumulation, and induces oxidative stress. CMPF reverses hepatic lipid accumulation and improves insulin sensitivity in obese mice[1][2].

CAS Number

86879-39-2

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cmpf.html

Purity

99.57

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)CCC1=C(C(O)=O)C(C)=C(CCC)O1

Molecular Formula

C12H16O5

Molecular Weight

240.25

References & Citations

[1]Prentice KJ, et al. The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction. Cell Metab. 2014 Apr 1;19 (4) :653-66.|[2]Prentice KJ, et al. CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis. EBioMedicine. 2018 Jan;27:200-213.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite

Chemical Information

3-Carboxy-4-Methyl-5-Propyl-2-Furanpropanoic Acid

2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid is a furoic acid that is furan-3-carboxylic acid substituted by a methyl group at position 4, a propyl group at position 5 and a 2-carboxyethyl group at position 2. It is a potent uremic toxin that has been found to accumulate in human serum of patients with chronic kidney diseases. It has a role as a uremic toxin and a human metabolite. It is a dicarboxylic acid and a furoic acid. It is a conjugate acid of a 3-carboxy-4-methyl-5-propyl-2-furanpropionate(2-) and a 3-carboxy-4-methyl-5-propyl-2-furanpropanoate.

CAS Number	86879-39-2
PubChem CID	123979
IUPAC Name	2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid
Molecular Formula	C12H16O5
Molecular Weight	240.25
XLogP	1.9
Topological Polar Surface Area	87.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Heavy Atom Count	17
Formal Charge	0
Complexity	289

SMILES

CCCC1=C(C(=C(O1)CCC(=O)O)C(=O)O)C

InChI

InChI=1S/C12H16O5/c1-3-4-8-7(2)11(12(15)16)9(17-8)5-6-10(13)14/h3-6H2,1-2H3,(H,13,14)(H,15,16)

InChIKey

WMCQWXZMVIETAO-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 86879-39-2

CID: 123979

Formula: C12H16O5

MW: 240.25

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	240.25
XLogP3	1.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	240.09977361
Monoisotopic Mass	240.09977361
Topological Polar Surface Area	87.7 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	289
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-120137-01	CMP-5
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HY-136258-01	NAChR agonist CMPI (hydrochloride)
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HY-112944A	CMP-SiaNAz (sodium)
HY-113846A-01	CMP-5 (dihydrochloride)

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