Products for Research Use Only
RegisterLogin

CMP8

CAT: 0804-HY-110392Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-110392Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CMP8, a selective ligand for estrogen receptor, binds to the mutant estrogen receptor ligand binding domain (ERLBD) . CMP8 exhibits IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively[1][2].
CAS Number
851107-28-3
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cmp8.html
Solubility
10 mM in DMSO
Smiles
O=C1CCC2(CC3=CC=C(Cl)C=C3)CC4=C(C=CC(O)=C4)C2=C1C5=CC=C(OCCN6CCCCC6)C=C5
Molecular Formula
C33H34ClNO3
Molecular Weight
528.08
References & Citations
[1]Miyazaki Y, et al. Destabilizing domains derived from the human estrogen receptor. J Am Chem Soc. 2012 Mar 7;134 (9) :3942-5.|[2]Kinzel O, et al. A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies. J Med Chem. 2006 Sep 7;49 (18) :5404-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; ERβ

Related Products

CatalogName
HY-129297-01CMPF
HY-136257-01CMP98
HY-1318115'-CMPS
HY-W654119CMPF-d3
HY-129297SCMPF-d5
HY-141659-01CMPD-39
HY-141659A-01(R) -CMPD-39
HY-120137-01CMP-5
HY-131796-013'-CMP
HY-136258-01NAChR agonist CMPI (hydrochloride)

Alternative Products

CatalogName
B2328-1CMP8

Popular Products