MBQ-167

• UNSPSC Description:

  MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.

• Target Antigen:

  CDK; Ras

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;GPCR/G Protein;MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/MBQ-167.html

• Purity:

  99.86

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CCN1C2=C(C3=C1C=CC=C3)C=C(N4N=NC=C4C5=CC=CC=C5)C=C2

• Molecular Weight:

  338.41

• References & Citations:

  [1]Humphries-Bickley T, et al. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther. 2017 May;16(5):805-818.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Phase 1

• CAS Number:

  2097938-73-1