JPHM-2-167

• Description :

  JPHM-2-167 (Compound 11) is a selective PHD (prolyl hydroxylase domain enzyme) inhibitor. JPHM-2-167 inhibits PHD2, PHD3 with IC50s of 0.253 μM and 3.95 μM, respectively. JPHM-2-167 can be used for chronic kidney disease [1].

• UNSPSC :

  12352005

• Target :

  HIF/HIF Prolyl-Hydroxylase

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Smiles :

  O=C(N(C1=CC=C(C2=CC=CC=C2)C=C1)C(N3C4=NC=CC=N4)=O)C3(CC5)CCN5CC6=NC=CC=C6C

• Molecular Formula :

  C30H28N6O2

• Molecular Weight :

  504.58

• References & Citations :

  [1]Xu J, et al. Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia. J Med Chem. 2024 Jan 25;67 (2) :1393-1405.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1258877-17-6]