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MBQ-167

CAT: 0804-HY-112842-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-112842-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.
CAS Number
2097938-73-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK; Ras
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MBQ-167.html
Concentration
10mM
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCN1C2=C(C3=C1C=CC=C3)C=C(N4N=NC=C4C5=CC=CC=C5)C=C2
Molecular Formula
C22H18N4
Molecular Weight
338.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Humphries-Bickley T, et al. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther. 2017 May;16 (5) :805-818.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CDC

Chemical Information

Mbq-167

Rac/Cdc42 Inhibitor MBQ-167 is an orally bioavailable inhibitor of the Rho GTPases Ras-related C3 botulinum toxin substrate (Rac) and cell division control protein 42 homolog (Cdc42), with potential antineoplastic activity. Upon oral administration, Rac/Cdc42 inhibitor MBQ-167 targets, binds to and inhibits the activity of the GTP-binding proteins Rac and Cdc42 that are expressed on certain cancer cells and immunosuppressive immune cells in the tumor microenvironment (TME). This inhibits p21-activated kinase (PAK) and signal transducer and activator of transcription 3 (STAT3) signaling, induces cell-cycle arrest and apoptosis, and inhibits cancer cell proliferation and migration. MBQ-167 also reduces tumor-infiltrating macrophages and myeloid-derived suppressor cells (MDSCs) in the TME, which may abrogate the immunosuppressive nature of the TME. Rac and Cdc42, overexpressed or hyperactivated in various cancers, are homologous, small GTPases that regulate epithelial to mesenchymal transition, cell migration, invasion, and cell cycle progression and metastasis.

CAS Number2097938-73-1
PubChem CID129896932
IUPAC Name9-ethyl-3-(5-phenyltriazol-1-yl)carbazole
Molecular FormulaC22H18N4
Molecular Weight338.4
XLogP4.7
Topological Polar Surface Area35.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity477
SMILES
CCN1C2=C(C=C(C=C2)N3C(=CN=N3)C4=CC=CC=C4)C5=CC=CC=C51
InChI
InChI=1S/C22H18N4/c1-2-25-20-11-7-6-10-18(20)19-14-17(12-13-21(19)25)26-22(15-23-24-26)16-8-4-3-5-9-16/h3-15H,2H2,1H3
InChIKey
LJCANTASZGYJLG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mbq-167
CAS: 2097938-73-1
CID: 129896932
Formula: C22H18N4
MW: 338.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight338.4
XLogP34.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass338.153146591
Monoisotopic Mass338.153146591
Topological Polar Surface Area35.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity477
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
XID93873-01MBQ-167
A16808-2MBQ-167 2mg
A16808-100MBQ-167 100mg
A16808-5MBQ-167 5mg
A16808-50MBQ-167 50mg
A16808-25MBQ-167 25mg
A16808-10MBQ-167 10mg
A16808-1MBQ-167 1mg
TBI4434-5MGMBQ-167, Rac/Cdc42 inhibitor

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